Pipeline

RNA therapeutics for complex diseases

At Nutcracker Therapeutics, we are driven by the unique opportunity that RNA offers to develop best-in-class medicines that will improve human health around the world. Because the promise of RNA isn’t the future, it’s now.

Pipeline

Nutcracker Therapeutics is seeking pharmaceutical partners to further develop its proprietary assets.

Program

Program

Discovery

Lead candidate identification

IND-enabling studies

Phases 1-3

NTX-250

Target

HPV16 E6/E7, IL-12, LIGHT

Modality

Locally delivered, mRNA encoded immunotherapy with engineered LIGHT +IL-12

Indication

High-grade cervical dysplasia, HPV-driven tumors

Discovery Lead candidate identification IND-enabling studies Phases 1-3

NTX-470

Target

PSMA-STEAP1 T Cell engager

Modality

Systemically delivered, mRNA encoded multi-specific protein

Indication

Metastatic, castration resistant prostate cancer

Discovery Lead candidate identification IND-enabling studies Phases 1-3

NTX-472

Target

aCD19-aCD20-SIRPα

Modality

Systemically delivered, mRNA encoded multi-specific protein

Indication

Auto-immune disease; R/R B cell lymphoma

Discovery Lead candidate identification IND-enabling studies Phases 1-3